What is dicoumarol used for?
Dicoumarol is an anticoagulant that acts as a vitamin K antagonist by inhibiting its bioavailability. While high doses of dicoumarol can result in uncontrolled bleeding, it has been utilized in therapeutic doses as an anticoagulant treatment for deep vein thrombosis and other blood clotting disorders.
Is dicoumarol a warfarin?
Dicoumarol, a symmetrical biscoumarin can be considered as the “parent” of the widely used anticoagulant drug, warfarin. The discovery of dicoumarol’s bioactive properties resulted from an investigation into a mysterious cattle disease in the 1940s.
What are the side effects of Dicumarol?
low vitamin K levels. anemia. increased risk of bleeding due to clotting disorder. an increased risk of bleeding.
Is Dicumarol a coumarin?
Dicumarol is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X).
Is dicoumarol still used?
Dicoumarol itself, for a short time, was employed as a medicinal anticoagulant drug, but since the mid-1950s has been replaced by its simpler derivative warfarin, and other 4-hydroxycoumarin drugs.
Why is warfarin still used?
Warfarin helps to prevent the clots from forming. People who are prone to blood clots in the circulation outside the heart are also often prescribed warfarin: for example, people who have had deep vein thrombosis (DVT) and those who have had clots travel to the lungs, causing a pulmonary embolism.
Is dicoumarol the same as Coumadin?
Not to be confused with Coumadin or coumarin. Dicoumarol ( INN) or dicumarol ( USAN) is a naturally occurring anticoagulant drug that depletes stores of vitamin K (similar to warfarin, a drug that dicoumarol inspired). It is also used in biochemical experiments as an inhibitor of reductases .
What is the solubility of dicoumarol?
Dicoumarol is a competitive NADH quinone oxidoreductase (NQO1) inhibitor. * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values.
How long does it take for dicoumarol to work?
Dicoumarol itself, for a short time, was employed as a medicinal anticoagulant drug, but since the mid-1950s has been replaced by its simpler derivative warfarin, and other 4-hydroxycoumarin drugs. It is given orally, and it acts within two days.