What is hippocampal avoidance?
Hippocampus-avoidance WBRT (HA-WBRT) selectively restricts the radiation dose in the hippocampal region with the intention of preserving cognitive functions. It is generally considered a safe method, with a low risk of hippocampal and peri-hippocampal relapse (10, 14–16).
What is hippocampal sparing radiation?
Hippocampal-sparing was defined as a mean dose to at least one hippocampus of less than 30 Gy. The dose delivered to the tumour was never compromised to achieve the hippocampal dose constraint. Logistic regression analyses were performed to identify predictive factors for achieving hippocampal-sparing treatment.
How long is whole brain radiation treatment?
Whole-brain radiation. People undergoing whole-brain radiation usually require 10 to 15 treatments over two to three weeks. Side effects may include fatigue, nausea and hair loss. Long-term, whole-brain radiation is associated with cognitive decline.
What does the hippocampus do in your brain?
Hippocampus is a complex brain structure embedded deep into temporal lobe. It has a major role in learning and memory. It is a plastic and vulnerable structure that gets damaged by a variety of stimuli. Studies have shown that it also gets affected in a variety of neurological and psychiatric disorders.
How do you contour a hippocampus?
A Step-by-Step Guide to Contouring the Hippocampus
- Step 1: Find the Slice With a Good View of the Temporal Horn.
- Step 2: Contour Inferiorly From the Level of the Temporal Horn.
- Step 3: Contour Superiorly From the Level of the Temporal Horn.
Does whole brain radiation improve survival?
Whole brain radiation therapy does not improve the overall survival of EGFR-mutant NSCLC patients with leptomeningeal metastasis | Radiation Oncology | Full Text.
What disorders are associated with the hippocampus?
Neuroimaging and neuropsychological studies have, among other observations, implicated the hippocampal formation in Alzheimer’s disease, temporal lobe epilepsy (TLE), cognitive ageing, post-traumatic stress disorder (PTSD), transient global amnesia, schizophrenia, and depressive and anxiety disorders.
What are the side effects of full brain radiation?
The side effects of whole brain radiation therapy may not be noticeable until a few weeks after treatment begins….Radiation to the brain can cause these short-term side effects:
- Headaches.
- Hair loss.
- Nausea.
- Vomiting.
- Extreme tiredness (fatigue)
- Hearing loss.
- Skin and scalp changes.
- Trouble with memory and speech.
Is hippocampus damage reversible?
A small hippocampus may have altered neuronal morphology, which is dynamic and reversible, as emphasized by responding to treatments and interventions that include antidepressant therapy, diet, and cognitive challenges.