What is NTRK1 gene?
The NTRK1 gene provides instructions for making a protein that is essential for the development and survival of nerve cells (neurons), especially those that transmit information about sensations such as pain, temperature, and touch (sensory neurons).
What does NTRK1 stand for?
NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1) is a Protein Coding gene. Diseases associated with NTRK1 include Insensitivity To Pain, Congenital, With Anhidrosis and Thyroid Carcinoma, Familial Medullary. Among its related pathways are Neurotrophic factor-mediated Trk receptor signaling and GPCR Pathway.
What is the Function of Tyrosine kinase receptors?
Receptor tyrosine kinases (RTKs) are a group of membrane-bound receptors that play an important role in the normal function of cells. They act as signal transducers that mediate cell-to-cell communication by phosphorylating tyrosine residues on key intracellular substrate proteins.
What is the NGF gene?
The NGF gene provides instructions for making a protein called nerve growth factor beta (NGFβ). This protein is important in the development and survival of nerve cells (neurons), especially those that transmit pain, temperature, and touch sensations (sensory neurons).
What type of receptor is TrkA?
TrkA is the high affinity catalytic receptor for the neurotrophin, Nerve Growth Factor, or “NGF”. As a kinase, TrkA mediates the multiple effects of NGF, which include neuronal differentiation, neural proliferation, nociceptor response, and avoidance of programmed cell death.
How do tyrosine kinases activate signaling proteins?
In particular, the binding of a signaling molecule with an RTK activates tyrosine kinase in the cytoplasmic tail of the receptor. This activity then launches a series of enzymatic reactions that carry the signal to the nucleus, where it alters patterns of protein transcription.
How do tyrosine kinase receptors become activated?
Generally, RTKs are activated through ligand-induced oligomerization, typically dimerization, which juxtaposes the cytoplasmic tyrosine kinase domains [3].
What cells secrete NGF?
SCs are glial cells that exist in the peripheral nervous system, which secrete NGF, BDNF, ciliary neurotrophic factor, basic fibroblast growth factor, and other neurotrophic factors[14].
What is ALK gene mutation?
ALK is short for anaplastic lymphoma kinase. It’s a mutation in the DNA of your lung cells that happens when two genes become fused, or stuck together. When you have this mutation, your lung cells make too many copies of themselves. These cells are cancerous and can spread to other parts of your body.
What is the ALK pathway?
Anaplastic lymphoma kinase (ALK) is an enzyme that is encoded by the ALK gene in humans. Discovered in 1994, it was first identified as a receptor tyrosine kinase in a chromosomal translocation associated with some anaplastic large cell lymphomas(ALCL), where ALK takes its name.
Where is trkA expressed?
trkA is expressed in a subgroup of DRG neurons that is assumed to be nociceptive, based on indirect evidence including (1) their relatively small size; (2) trkA expression in primary afferent fibers mainly in superficial dorsal horn (Averill et al., 1995; Molliver et al., 1995), a region associated with nociceptive …
What is the function of trkA?
Target-derived neurotrophin nerve growth factor (NGF) and its receptor TrkA are well known for retrograde signaling to promote survival and innervation of sympathetic and sensory neurons.
How do tyrosine kinases work?
Tyrosine kinases are enzymes that selectively phosphorylates tyrosine residue in different substrates. Receptor tyrosine kinases are activated by ligand binding to their extracellular domain. Ligands are extracellular signal molecules (e.g. EGF, PDGF etc) that induce receptor dimerization (except Insulin receptor).
What activates tyrosine kinase?
Receptor tyrosine kinases are activated by ligand binding to their extracellular domain. Ligands are extracellular signal molecules (e.g. EGF, PDGF etc) that induce receptor dimerization (except Insulin receptor). Different ligands employ different strategies by which they achieve the stable dimeric conformation.
What stimulates NGF?
Quercetin – said to promote nerve growth, and has shown the ability to regenerate peripheral nerves [47, 48]. Lion’s Mane (Hericium erinaceus) – An edible mushroom that might boost NGF in animals [50]. Zinc – Zinc may increase NGF in animals; however, memory was improved only when Vitamin A was sufficient [51].
What is the primary high affinity receptor for NGF?
It is worth noting that, although unconventional, the NGF DD arrangement closely resembles that being observed in the crystal structure of FGF1 (fibroblast growth factor) in complex with its high affinity receptor (FGFR2).
What is the NTRK1 gene?
Learn more The NTRK1 gene provides instructions for making a protein that is essential for the development and survival of nerve cells (neurons), especially those that transmit information about sensations such as pain, temperature, and touch (sensory neurons). The NTRK1 protein is found on the surface of cells, particularly sensory neurons.
What is the function of receptor tyrosine kinase?
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems th rough regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand 1, 2, 3, 4, 5, 6, 7, 8.
Do genes with at least one transcript encode a secreted protein?
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein (s) are secreted or actually retained in intracellular locations or membrane-attached.
Where are the low complexity regions on the protein scale?
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.