What is the function of MYC?
MYC gene encodes a multifunctional, nuclear phosphoprotein that controls a variety of cellular functions, including cell cycle, cell growth, apoptosis, cellular metabolism and biosynthesis, adhesion, and mitochondrial biogenesis.
How is myc activated?
Later, MYC was illustrated to be activated through chromosomal translocation in Burkitt lymphoma (see Conacci-Sorrell et al. 2014). MYC is also commonly activated in tumorigenesis as a consequence of both oncogenic and epigenetic events (Boxer and Dang 2001; Eilers and Eisenman 2008; Dang 2012).
What are MYC factors?
C-Myc. The Myc family includes four transcription factors, c-Myc, N-Myc, L-Myc, and S-Myc, involved in the control of cell growth, differentiation, and apoptosis.
How does myc activate p53?
c-myc was shown previously to influence the cellular response to p53 activation by inhibiting p21 expression and favoring apoptosis over cell cycle arrest (37). Hence, c-myc repression by p53 may constitute an integral component of the signaling pathway through which p53 promotes cell cycle arrest.
How does myc regulate apoptosis?
Unbridled MYC expression can activate the oncogene-stress pathway that signals via the p14ARF/MDM2 pathway to stimulate p53-mediated apoptosis. However, MYC levels in normal cells typically do not reach levels high enough to activate the p14ARF tumor suppressor.
What are Myc factors?
How does myc influence metabolism?
As a growth-promoting transcription factor, MYC stimulates metabolic pathways that support formation of new organelles, particularly ribosomes and mitochondria, which in turn is required for ATP generation and the production of many substrates for cell growth (152).
How does myc affect the cell cycle?
Promotion of the cell cycle is a major oncogenic mechanism of the oncogene c-MYC (MYC). MYC promotes the cell cycle by not only activating or inducing cyclins and CDKs but also through the downregulation or the impairment of the activity of a set of proteins that act as cell-cycle brakes.