What is the ligand for integrins?
Tarui T, Mazar AP, Cines DB, Takada Y: Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction. J Biol Chem. 2001, 276: 3983-3990. 10.1074/jbc.
What does an integrin receptor bind to?
the extracellular matrix
Integrins are the principal receptors used by animal cells to bind to the extracellular matrix. They are heterodimers and function as transmembrane linkers between the extracellular matrix and the actin cytoskeleton. A cell can regulate the adhesive activity of its integrins from within.
Which integrins bind to RGD?
A subset of the integrins recognize the RGD motif within their ligands, the binding of which mediates both cell-substratum and cell-cell interactions. These integrins include αvβ3, α5β1 and αIIbβ3. The RGD domain is both sufficient and indispensable for cell membrane binding.
What do integrins link together?
Integrins link the actin cytoskeleton of a cell to various external structures. The cytoplasmic portion of each integrin molecule binds to adaptor proteins that connect to the actin filaments inside the cell.
Is fibronectin an integrin ligand?
Fn is a known ligand for many integrin receptors, linking the ECM with the intracellular cytoskeleton.
What does RGD peptide bind?
RGD is the principal integrin-binding domain present within ECM proteins such as fibronectin, vitronectin, fibrinogen, osteopontin, and bone sialoprotein [3].
What is the significance of the presence of an RGD motif in an integrin ligand?
The RGD motif acts as a specific ligand for an integrin family (αvβ3) known to be overexpressed both in angiogenic endothelial cells and tumor cells, including gliomas.
Is integrin a fibronectin?
The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin. J Cell Biol. 1993 Jul;122(1):235-42.
What is RGD tripeptide?
The tripeptide Arg-Gly-Asp (RGD) was originally identified as the sequence within fibronectin that mediates cell attachment. The RGD motif has now been found in numerous other proteins and supports cell adhesion in many, but not all, of these.
What is the role of the RGD peptide motif?
RGD peptides and mimetics, in addition to providing insights into the fundamental mechanisms of cell adhesion, are potential therapeutic agents for the treatment of diseases such as thrombosis and cancer.
What is the role of RGD?
RGD is involved in cell attachment, cell spreading, actin-skeleton formation, and focal-adhesion formation with integrins. These four overlapped reactions are important for transmitting signals related to cell behavior and the cell cycle [13].
What are integrin molecules?
Integrins are transmembrane receptors that facilitate cell-cell and cell-extracellular matrix (ECM) adhesion.
How many integrins are there?
24 different integrins
The members of the human integrin superfamily and how they combine to form heterodimeric integrins. At least 18 α subunits and eight β subunits have been identified in humans, which are able to generate 24 different integrins.
What are selectin ligands?
The prototype selectin ligand is a tetrasaccharide, sialyl Lewis X (sLex). They also bind with high affinity to glycans in proteoglycans and glycoproteins. The best characterized ligand or a counterreceptor is a mucin-like glycoprotein, P-selectin glycoprotein ligand-1 (PSGL-1), expressed on most lymphocytes.