What type of transcription factor is YY1?
zinc-finger transcription factor
YY1 is a ubiquitous and multifunctional zinc-finger transcription factor (also known as δ, NF-E1, UCRBP, and CF1) member of the Polycomb Group protein family, a group of homeobox gene receptors that play critical roles in hematopoiesis and cell cycle control.
Is YY1 a repressor?
YY1 (Yin Yang 1) is a transcriptional repressor protein in humans that is encoded by the YY1 gene.
Is YY1 a co activator?
YY1 can act as transcription activator (A), repressor (B) and coactivator (C, with the PSA promoter as an example). Other coactivators (designated as CoAc1 and CoAc2) can be recruited by YY1 to facilitate AR-mediated PSA transcription.
What does a transcription factor do?
Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase, that initiate and regulate the transcription of genes.
What is the main difference between general and regulatory transcription factors?
General transcription factors are essential for any transcription for all genes while regulatory transcription factors regulate transcription of specific genes. General transcription factors only regulate the housekeeping genes while regulatory transcription factors control all of the other genes.
What is a transcription factor quizlet?
Transcription Factors. The proteins that bind to DNA regulatory elements (promoter, enhancer) to activate or repress transcription.
What is the function of transcription factor?
What is the role of zinc finger?
Zinc finger proteins are among the most abundant proteins in eukaryotic genomes. Their functions are extraordinarily diverse and include DNA recognition, RNA packaging, transcriptional activation, regulation of apoptosis, protein folding and assembly, and lipid binding.
How does YY1 activate gene transcription?
YY1 may directly activate gene transcription by binding to gene promoters and/or transcription factors that stimulate YY1-mediated transcriptional activation. Known examples include TATA-binding protein, TBP-associated factor II55, and transcription factor IIB.
What is the function of YY1?
By tethering to DNA promoters, YY1 regulates a variety of cellular and viral genes ( Donohoe et al., 1999; Nguyen et al., 2004 ). What distinguishes this protein from other transcription factors is its ability to not only initiate transcription but also regulate it through activation or repression.
What is the scientific name for the factor YY1?
Shi et al. (1991) formally named the factor YY1. During the preparation of the manuscript, Shi et al. (1991) learned that YY1 had been cloned by two additional laboratories. Park and Atchison (1991) have identified and cloned the protein, which they termed NF-E1, based on its ability to bind within the Ig κ 3′ enhancer ( Park and Atchison, 1991 ).
What is the molecular weight of YY1?
The YY1 gene consists of five highly conserved exons encoding a protein of 414 amino acids in length, and an estimated molecular weight of 44 kDa. However, due to the structure of the protein, SDS–polyacrylamide gel analysis reveals its weight to be 68 kDa ( Shi et al., 1997 ).