What are C3H HeJ mice?
C3H/HeJ mice, commonly called C3H, are used as a general purpose strain in a wide variety of research areas including cancer, infectious disease, sensorineural, and cardiovascular biology research.
Are C57BL 6 mice immunocompetent?
C57BL/6 mice, in particular, are notable for their immunogenicity due to the initial strain development goal being their use in the study of cancer and immune responses.
How is a Substrain presented?
Substrains are designated by specific nomenclature to help researchers identify their origin and history. Substrains are designated by appending a laboratory code (e.g. J for The Jackson Laboratory) to the end of a strain name without an additional forward slash.
What are diversity outbred mice?
Diversity Outbred mice were generated by breeding eight founder inbred strains together to produce a population with a random assortment of genetics (Figure 2). The eight founder strains were chosen specifically because of their unique characteristics.
What is the meaning of Substrain?
a substance or surface which an organism grows and lives on and uses as food. biology. A substrate is also a substance which an enzyme (= substance produced by living cells) acts on to produce a chemical reaction. (Definition of substrate from the Cambridge Academic Content Dictionary © Cambridge University Press)
What is inbred mouse?
Inbred strains of mice are defined as strains that have been maintained by successive brother to sister matings over more than 20 generations (Green, 1975). Repetitive inbreeding removes genetic heterogeneity, so that mice of an inbred strain are considered to be genetically identical to each other.
Is the authoritative source of official names for mouse genes alleles and strains?
The Mouse Genome Informatics Database is the authoritative source of official names for mouse genes, alleles, and strains. Nomenclature follows the rules and guidelines established by the International Committee on Standardized Genetic Nomenclature for Mice.
What are Black 6 mice?
C57BL/6, often referred to as “C57 black 6”, “C57” or “black 6”, is a common inbred strain of laboratory mouse.
What is cd1 mouse?
CD-1 IGS mice are outbred mice derived from a group of outbred Swiss mice developed at the Anti-Cancer Center in Lausanne, Switzerland. They were imported to the US in 1926 and to Charles River in 1959. The CD-1 IGS mice are generally used for genetics, toxicology, pharmacology, and aging research.
What is the meaning of outbred?
to breed (animals that are not closely related) or (of such animals) to be bred.
What is an outbred population?
The Diversity Outbred (DO) population is a heterogeneous stock derived from the same eight founder strains as the Collaborative Cross (CC) inbred strains. Genetically heterogeneous DO mice display a broad range of phenotypes.
What is a CD 1 mouse?
What is a synonym for substrate?
media, medium, bottom, support, basis, substance.