What are the side effects of Lotronex?
Common side effects of Lotronex include:
- headache.
- stomach upset or discomfort.
- hemorrhoids.
- bloating.
- gas.
- nausea.
- constipation.
- burping with heartburn.
How do you take Lotronex?
To lower the risk of constipation, LOTRONEX should be started at a dosage of 0.5 mg twice a day. Patients who become constipated at this dosage should stop taking LOTRONEX until the constipation resolves. They may be restarted at 0.5 mg once a day.
What is Alosetron used for?
Alosetron is used to treat irritable bowel syndrome (IBS) in women who have diarrhea as their main symptom. This medicine is only used in severe cases of IBS that have not responded to other therapy. IBS is also known as irritable colon or spastic colon.
Is Lotronex still on the market?
Alosetron hydrochloride (Lotronex), a prescription drug manufactured by GlaxoWellcome, and used to treat irritable bowel syndrome in women, has been withdrawn after reports of serious complications.
Why was alosetron removed from the market?
Glaxo’s decision to pull the drug comes after further FDA analysis of post-marketing reports of patients taking alosetron, including 49 cases of ischemic colitis and 21 cases of severe constipation, resulting in 34 hospitalizations without surgery, 10 surgeries, and three deaths.
How much does Lotronex cost?
The cost for Lotronex oral tablet 0.5 mg is around $926 for a supply of 30 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
What kind of drug is Lotronex?
Alosetron (Lotronex) is an antidiarrheal medication that blocks serotonin receptors in the gut. This lessens abdominal discomfort, pain, and diarrhea.
Is Alosetron still available?
Why is Alosetron only used in females?
In contrast to age, sex was associated with significant differences in the pharmacokinetics of alosetron, independent of smoking habit and body weight. The clearance of alosetron by metabolism was lower in women than in men.
Is there a generic for Lotronex?
Lotronex (Generic: Alosetron) IBS Drug Side Effects and Dosage.
Why was Lotronex taken off the market?
Lotronex was taken off the market on Nov. 28, less than 10 months after being approved by the Food and Drug Administration. About 300,000 people had taken it. It was withdrawn because about 70 patients had developed severe constipation or ischemic colitis, a lack of blood flow to the colon.
Can alosetron be used in males?
Conclusions: Alosetron was effective in these men and women with IBS. constipation was the most frequently reported adverse event associated with alosetron therapy. Ischemic colitis and serious complications of constipation were reported in a small number of patients treated with alosetron.