What is mesna infusion used for?
Mesna is used to reduce the risk of hemorrhagic cystitis (a condition that causes inflammation of the bladder and can result in serious bleeding) in people who receive ifosfamide (a medication used for the treatment of cancer). Mesna is in a class of medications called cytoprotectants.
Is mesna a chemo?
Mesna is a drug given with some types of chemotherapy to help protect the bladder from irritation.
How does mesna work?
Mesna helps to protect the lining of the bladder against damage from ifosfamide. The body breaks down ifosfamide to form a product that can harm the bladder, and mesna works by making this product less harmful.
How often is mesna given?
If necessary the dose of mesna can be increased to 40% of the oxazaphosphorine dose given four times at three hourly intervals (0, 3, 6 and 9 hours). (Total dose = 160% (w/w) of the oxazaphosphorine dose).
Is mesna toxic?
Common side effects include headache, vomiting, sleepiness, loss of appetite, cough, rash, and joint pain. Serious side effects include allergic reactions. Use during pregnancy appears to be safe for the baby but this use has not been well studied. Mesna is an organosulfur compound.
When do you need mesna with cyclophosphamide?
Mesna should always be given with ifosfamide and high dose cyclophosphamide if hyperhydration is not being used.
What is the meaning of mesna?
Listen to pronunciation. (MEZ-nuh) A drug used to prevent hemorrhagic cystitis (bleeding in the bladder) caused by the anticancer drug ifosfamide. Mesna helps protect healthy tissue from some of the side effects caused by certain anticancer drugs.
Can mesna be given orally?
Oral mesna is taken by mouth, usually 2 and 6 hours after you receive ifosfamide. Mesna is given either in a series of 3 injections spaced 4 hours apart, or as a single injection followed by 2 oral doses spaced 2 and 6 hours later. Follow your doctor’s dosing instructions very carefully.
What is mesna full form?
The name of the substance is an acronym for 2-mercaptoethane sulfonate Na (Na being the chemical symbol for sodium).
Is mesna effective?
A total of 68 cycles of cyclophosphamide were given with mesna, with a median of three cycles per patient. A recurrence of cystitis was prevented in all but one patient. Thus, mesna is effective in preventing recurrent cystitis in patients receiving further cyclophosphamide.
Can IV mesna be given orally?
Following an initial IV bolus, mesna injection PO is given at a dosage of 40% (w/w) of the ifosfamide dose 4 and 8 hours after ifosfamide administration. It is not recommended to give mesna orally as the initial dose.
How does mesna prevent hemorrhagic cystitis?
Administration of Mesna (2-mercaptoethane sulfonate sodium) before initiation of cyclophosphamide can prevent hemorrhagic cystitis by binding to and neutralizing acrolein.