Does carboplatin cause ototoxicity?
For carboplatin, ototoxicity has been reported to occur at cumulative doses in excess of 400 mg/m2 [45]. In addition to the total dose administered, the mode of administration may also facilitate platinum acoustic damage.
Does cisplatin cause ototoxicity?
Cisplatin is a chemotherapeutic agent used in the treatment of solid tumors like ovarian, testicular, cervical, lung, head and neck and bladder cancers. Dose limiting side effects of cisplatin include nephrotoxicity, neurotoxicity and ototoxicity.
Does gentamicin cause ototoxicity?
Gentamicin ototoxicity, leading to hearing loss or deranged vestibular function, has been widely reported and is often irreversible. The prevalence of clinically evident ototoxicity with multiple daily regimens has been estimated at 11%.
Is gentamicin an ototoxic drug?
Gentamicin is a member of the family of antibiotics called aminoglycosides. All aminoglycosides are ototoxic.
Does carboplatin cause hearing loss?
Hearing loss affects one in five patients treated with cisplatin and nearly one in five patients with carboplatin, Dr. Schink says. The drugs also are associated with tinnitus, a condition that causes noise or ringing in the ears. Hearing loss or tinnitus caused by the drugs typically doesn’t go away.
Does cisplatin always cause hearing loss?
Hearing-related side effects to this medication appear fairly common: Permanent hearing loss occurs in about half of all patients who take cisplatin, ASHA notes.
How can cisplatin ototoxicity be prevented?
Sodium thiosulfate is a type of drug called an antioxidant. It is thought to bind to harmful molecules called reactive oxygen species that are produced in cells that have taken up cisplatin. This binding may prevent free radicals from damaging the hair cells in the inner ear that play a critical role in hearing.
Which antibiotics cause nephrotoxicity and ototoxicity?
The aminoglycoside antibiotic gentamicin can cause both ototoxicity and nephrotoxicity, the severity of which varies with circadian time of daily treatment. However, it is not yet resolved if such drug-induced adverse effects are independent or dependent phenomena.
Does cisplatin cause hearing loss?
But cisplatin and other similar platinum-containing drugs can damage the cochlea, leaving 40%–80% of adults, and at least 50% of children, with significant permanent hearing loss, a condition that can greatly affect quality of life.
How common is hearing loss with cisplatin?
The large number of variables involved means that permanent hearing loss can occur in anywhere from 20-90% of cisplatin-treated patients.
Can cisplatin cause ringing in ears?
Which antibiotic is most likely to cause damage to the ear?
The Problems with Certain Antibiotics Along with chemotherapy drugs, loop diuretics and nonsteroidal anti-inflammatory drugs (NSAIDs), aminoglycoside antibiotics such as gentamicin are one of the most ototoxic groups of drugs regularly prescribed. Their use can lead to temporary or permanent hearing loss and tinnitus.
Why is gentamicin nephrotoxic?
Gentamicin induces nephrotoxicity by inhibiting protein synthesis in renal cells that specifically causes necrosis of cells in the renal proximal tubule, resulting in acute tubular necrosis, followed by acute renal failure.
Does carboplatin cause tinnitus?
Conclusions. This large prospective study confirms that new tinnitus during treatment is associated with chemotherapy and with certain ototoxic antibiotic treatment. Cisplatin and carboplatin were found to be the most potent ototoxic agents causing tinnitus at much greater numbers than the other drugs studied.
Which client has the highest risk of developing ototoxicity secondary to gentamicin?
Our research has shown that gentamicin is still widely used at a major medical center and that three patient populations (neonates, women of reproductive age, and older adults) are at the greatest risk for developing gentamicin induced oto-toxicity.
How does cisplatin cause nephrotoxicity?
Cisplatin causes damage to nuclear and mitochondrial DNA and production of reactive oxygen species (ROS) which lead to activation of both mitochondrial and non-mitochondrial pathways of apoptosis and necrosis. Mitochondrial energetics are also disrupted by cisplatin and may contribute to nephrotoxicity.
Which is the most nephrotoxic aminoglycoside?
Choice of aminoglycoside The following rank order of nephrotoxicity has been reported, from most toxic to least toxic: neomycin > gentamicin ≥ tobramycin ≥ amikacin ≥ netilmicin > streptomycin [1].
Does cisplatin cause tinnitus?
About half of all patients who receive the chemotherapy drug cisplatin develop hearing-related side effects including hearing loss, tinnitus and vertigo. This is known as ototoxicity.
Is carboplatin a good alternative to cisplatin?
Background: Introduced into clinical usage in 1992 as a platinum analogue with a distinctively different toxicity profile from cisplatin, carboplatin has become a commonly preferred agent over cisplatin.
What is the role of carboplatin in the treatment of platinum resistance?
Carboplatin is a useful alternative in situations where cisplatin is contraindicated and this is not universally at the expense of efficacy. De novo and acquired platinum resistance is inevitable and understanding the mechanisms of resistance is essential in improving outcomes.
Is intraperitoneal cisplatin a good second-line palliative treatment for lung cancer?
Intraperitoneal cisplatin and carboplatin treatment have been compared in a retrospective study as second-line palliative treatment which showed both non-inferiority and similar toxicities ( Milczek et al., 2012 ).
Is cisplatin effective in the treatment of endometrial cancer?
In comparison with carboplatin, the use of cisplatin has been more extensively evaluated in the systemic management of endometrial cancer. A recent Cochrane review on chemotherapy for advanced, recurrent and metastatic disease identified 11 phase III studies and 80 phase II studies (Humber et al., 2007).