Why were the ovariectomized rats used in this experiment?
Ovariectomized rats were used in this experiment to ensure control over the hormones in the rats. Without the ovaries, the rats were not able to produce estrogen, and therefore had low baseline T scores already, since estrogen stimulates bone growth and protects against osteoprosis.
What happens to the rat’s vertebral bone density with saline injections?
The saline injections will not change the rat’s vertebral bone density (indicated by an unchanging T score).
Why did the normal rat develop a palpable goiter with the propylthiouracil injection?
Why did the normal rat develop a palpable goiter with the TSH injection? You correctly answered: The TSH receptors on the thyroid gland were excessively stimulated.
How could you treat a Thyroidectomized rat so that it functions like a normal rat?
The hypothalamus primarily secretes tropic hormones that stimulate the secretion of other hormones. How would you treat a thyroidectomized animal so that it functions like a “normal” animal? Provide the animal T4 supplements.
What would be the effects of estrogen administration on the ovariectomized rats?
Estrogen replacement in ovariectomized rats results in physiologically significant levels of circulating progesterone, and co-administration of progesterone markedly reduces the circulating estrogen. Endocrine. 1997 Apr;6(2):125-31. doi: 10.1007/BF02738955.
Which of the rats developed a goiter after injection with thyroxine explain?
The hypophysectomized rat will become hypothyroidic and develop a goiter. Which of the rats did not develop a goiter after injection with TSH? the thyroidectomized rat.
Which of the following improved the vertebral bone density of the rats?
Parathyroid hormone (1-34) increases vertebral bone mass, compressive strength, and quality in old rats.
Which of the rats developed a goiter after injection with thyroxine?
The Hypox rat became hyperthyroidic and developed a goiter, which is similar to the normal rat. The dose was too large. What was the effect of propylthiouracil (PTU) injections on the normal rat’s BMR?
What effect did TSH have on the TX and Hypox rats?
In the Hypox rat, the TSH will stimulate the thyroid to release thyroxine and increase metabolic rate. However, in the Tx rat, nothing will happen because thyroxine will not be produced since the thyroid gland was removed.
What was the effect of the thyroxine injections on the hypophysectomized rats BMR?
what was the effect of thyroxine injections on the mormal rat’s BMR? The hypophysectomized rat bmr increased with tsh. the bmr was just below the normal rat but still lower the syringe amount was a little too low.
What effect will the calcitonin injections have on the calcitonin treated rat?
Predict Question 3: What effect will the calcitonin injections have on the calcitonin-treated rat’s vertebral bone density? Your answer: The calcitonin injections will increase the rat’s vertebral bone density (indicated by a less-negative T score).
What is silastic capsule?
Silastic capsules are frequently used to study the physiologic effects of estrogen exposure in animal models. The Office of Laboratory Animal Welfare requires the sterilization of nonpharmaceutical-grade compounds before use.
Which of the rats did not develop a goiter after injection with TSH quizlet?
Which of the rats did not develop a goiter after injection with TSH? the thyroidectomized rat. How would you treat a thyroidectomized animal so that it functions like a “normal” animal? Provide the animal T4 supplements.
How is bone density test done?
During the scan, a large scanning arm will be passed over your body to measure bone density in the centre of the skeleton. As the scanning arm is moved slowly over your body, a narrow beam of low-dose X-rays will be passed through the part of your body being examined.
How is bone density measured?
What is a bone density test? A bone density test is used to measure bone mineral content and density. It may be done using X-rays, dual-energy X-ray absorptiometry (DEXA or DXA), or a special CT scan that uses computer software to determine bone density of the hip or spine.
Which of the rats developed a goiter after injection with thyroxine explain quizlet?
The Hypox rat became hyperthyroidic and developed a goiter, which is similar to the normal rat. The dose was too large.
What did the thyroxine injection do to the rats?
The thyroid activity of normal cold-exposed rats is reduced by the administration of 6 γ–15 γ of thyroxine per day, this substance acting by way of the pituitary. The cold reactions of the basophilic cells are regarded as a link in the physiological mechanisms that release increased thyroid activity.
What was the effect of thyroxine on the hypophysectomized rat?
The hypophysectomized rat had a lower baseline metabolic rate because removal of the pituitary gland, or hypophysis, prevented TSH production. Explain why thyroxine had these effects. The effect of thyroxine is to increase baseline metabolic rate.
What was the effect of thyroxine injections on the normal rat?
What was the effect of thyroxine injections on the normal rat’s BMR? Your answer: The rat became hyperthyroidic.
What does calcitonin do to calcium?
Calcitonin decreases calcium levels by blocking the breakdown of bone calcium and by preventing your kidneys from reabsorbing calcium. In other words, it encourages calcium loss through your kidneys.