What does isavuconazole treat?
Isavuconazole is a new extended-spectrum triazole with activity against yeasts, molds, and dimorphic fungi. It is approved for the treatment of invasive aspergillosis and mucormycosis.
Is isavuconazole a strong CYP3A4 inhibitor?
These results indicate that isavuconazole is a sensitive substrate and moderate inhibitor of CYP3A4.
Is Isavuconazonium the same as isavuconazole?
Isavuconazole or Cresemba™ is the newest azole antifungal approved that comes as the salt formulation isavuconazonium. The United States Food and Drug Administration approved isavuconazole in March of 2015 for the treatment of invasive aspergillosis and invasive mucormycosis.
What drugs interact with CYP2C9 and CYP3A4 enzymes?
Table 1-2: Examples of in vitro selective inhibitors for P450-mediated metabolism (9/26/2016)
| Enzyme | Inhibitor |
|---|---|
| CYP2C9 | Sulfaphenazole, Tienilic acid* |
| CYP2C19** | S-(+)-N-3-benzyl-nirvanol, Nootkatone, Ticlopidine* |
| CYP2D6 | Quinidine, Paroxetine* |
| CYP3A4/5 | Itraconazole, Ketoconazole, Azamulin*, Troleandomycin*, Verapamil* |
Does isavuconazole cover Candida?
In vitro, isavuconazole is highly active against bloodstream isolates of Candida spp. and has demonstrated good efficacy in animal models of candidiasis (20,–22).
What drug class is isavuconazole?
Isavuconazonium is in a class of medications called azole antifungals. It works by slowing the growth of fungi that cause infection.
What class of drug is isavuconazole?
Does isavuconazole prolong QTc?
Isavuconazole is a novel antifungal drug approved for the treatment of adults with invasive aspergillosis and mucormycosis. While azoles as a class effect are known to prolong QTc interval, clinical trials have shown that isavuconazole administration may cause shortening in a dose-related manner.
Are CYP3A and CYP3A4 the same?
CYP3A4 is the predominant isoenzyme present in the liver and contributes to the majority of CYP3A activity. In addition to the liver, CYP3A5 enzyme may be expressed significantly in the small intestine, kidney, and other organs contributing variably to the total CYP3A activity.