What is PANC 1 cell line?
PANC-1 is a cell line exhibiting epithelial morphology that was isolated from the pancreatic duct of a 56-year-old, White, male with epithelioid carcinoma. This cell line can be used in cancer research. Homo sapiens, human. Morphology epithelial Tissue Pancreas; Duct Disease.
What are AsPC 1 cells?
CRL-1682™ AsPC-1 is cell line derived from nude mouse xenografts initiated with cells from the ascites of a 62-year-old, White, female patient with cancer of the pancreas. This cell line can be used in cancer research. Homo sapiens, human.
What are MIA PaCa 2 cells?
MIA PaCa-2 is an epithelial cell line that was derived from tumor tissue of the pancreas obtained from a 65-year-old, White male. This cell line can be used in cancer research. Discounts are available for our fellow nonprofit organizations.
What are KPC mice?
The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDA) which develops many key features observed in human PDA including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells.
What are KP mice?
The KP-NINJA mouse maintains the disease relevance of the KP lung cancer model (Jackson et al., 2005) while forming immunogenic lung tumors that generate robust endogenous neoantigen-specific T cell responses.
What is KRAS G12D?
KRAS G12D is a predictive biomarker for use of afatinib, dacomitinib, erlotinib, gefitinib, osimertinib, cetuximab, and panitumumab in patients. Of the therapies with KRAS G12D as a predictive biomarker, 2 are FDA-approved and 7 have NCCN guidelines in at least one clinical setting.
How p53 works as a tumor suppressor?
The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.
What gene activates p53?
This is evidenced by reports that TP53, the gene that encodes for p53, is the most frequently mutated gene in cancer. p53 is activated in response to stress signals—DNA damage, oncogene activation, ribosomal stress and hypoxia4 —and leads to growth suppression by inducing cell cycle arrest or cell death.