What is the function of GLUT5?
GLUT5, an apically expressed transmembrane protein, facilitates fructose absorption by moving the sugar down a chemical gradient. Its cDNA has been cloned from the human, rabbit, rat, and mouse intestine.
Where are GLUT5 receptors found?
GLUT5 (SLC2A5) is a high-affinity fructose transporter primarily expressed at the apical surface of intestinal epithelial cells but also at lower levels in testis, kidney, brain, skeletal muscle and white adipose tissue (WAT)15.
What are GLUT2 and GLUT5?
Animal data has shown glucose transport protein 5 (GLUT5, Slc2a5) to be the main apical fructose transporter, while GLUT2 (Slc2a2) plays a facilitative and inducible role. 6,7. Other GLUT can also transport fructose, but are less relevant (GLUT7, 8, 9, 11, and 12).
What kind of transporter is GLUT5?
fructose transporter
GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine. GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose’s high concentration in the intestinal lumen.
Is GLUT5 insulin dependent?
Expression of GLUT5 in the intestine is highly regulated, showing circadian rhythm, dependence on dietary fat and carbohydrate content, and insulin levels. Interestingly, fructose does not regulate GLUT5 expression in adipose cells.
How does GLUT2 work?
GLUT2 is the major glucose transporter inĪ² -cells of pancreatic islets and hepatocytes. In both cell types, GLUT2 mediates the facilitated diffusion of glucose across the cell membranes, and then intracellular glucose metabolism is initiated by the glucose-phosphorylating enzyme, hexokinase IV or glucokinase.
Is GLUT5 active or passive?
The Main Fructose Transporter GLUT5 Fructose is transported passively across membranes by a member of the facilitative glucose transporter (GLUT) family, named GLUT5 (19, 20, 72, 98, 137).
Is GLUT5 a protein?
GLUT5, an apically expressed transmembrane protein, facilitates fructose absorption by moving the sugar down a chemical gradient.
Where are GLUT2 transporters found?
Abstract. The glucose transporter isoform GLUT2 is expressed in liver, intestine, kidney and pancreatic islet beta cells, as well as in the central nervous system, in neurons, astrocytes and tanycytes.
Is GLUT a carrier protein?
The GLUT or SLC2A family are a protein family that is found in most mammalian cells. 14 GLUTS are encoded by human genome. GLUT is a type of uniporter transporter protein….Glucose transporter.
| Available protein structures: | |
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| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
Is glut 5 active transport?
Glucose Transporter 5 GLUT5 is expressed at high levels in the apical membrane of intestinal enterocytes and mature spermatocytes in adults. Fructose is transported across intestinal epithelial cells by passive transport. A high rate of fructose utilization is also carried out by testes.
What do GLUT2 receptors do?
Is GLUT active transport?
There are two types of glucose transporters in the brain: the glucose transporter proteins (GLUTs) that transport glucose through facilitative diffusion (a form of passive transport), and sodium-dependent glucose transporters (SGLTs) that use an energy-coupled mechanism (active transport).