What does serum ferritin indicate?
Ferritin is a blood protein that contains iron. A ferritin test helps your doctor understand how much iron your body stores. If a ferritin test reveals that your blood ferritin level is lower than normal, it indicates your body’s iron stores are low and you have iron deficiency. As a result, you could be anemic.
Why is ferritin high in RA?
Thus, serum ferritin is an index of iron stores also in rheumatoid arthritis. In active disease, higher than expected values of serum ferritin are probably due to a shifting of iron from the circulating pool to the reticuloendothelial cells of the synovial membrane.
Does Low Iron affect coagulation?
The researchers found that low levels of iron in the blood were a strong risk factor for blood clots. Patients who took iron supplements did not have higher risk, suggesting that treatment for iron deficiency can prevent blood clots.
Is ferritin high or low with inflammation?
Ferritin is an acute phase reactant and a marker of acute and chronic inflammation. It is elevated in a wide range of inflammatory conditions, including chronic kidney disease, rheumatoid arthritis, and other autoimmune disorders, acute infections, and cancer [1, 2].
What is a high serum ferritin level?
Many laboratories consider serum ferritin levels greater than 200 ng/mL in women and greater than 300 ng/mL in men to be abnormal. However, a large percentage of the general population has a serum ferritin level between 200 and 1,000 ng/mL.
What autoimmune disease causes high ferritin levels?
Four uncommon immune mediated conditions may be associated with high ferritin levels: macrophage activation syndrome (MAS), adult onset Still’s disease (AOSD), catastrophic antiphospholipid syndrome (cAPS) and septic shock.
Does high ferritin cause blood clots?
Naturally occurring higher iron levels can offer protective benefits against high cholesterol and atherosclerosis—but can also increase your risk of blood clots and stroke.
How does iron affect coagulation?
Iron extends clotting of plasma by interacting with proteins of the coagulation cascade. Fe3+ and/or its hydrolytic species interact with fibrinogen and/or fibrin changing their morphology and properties.
What are symptoms of high ferritin levels?
Symptoms of excess ferritin include:
- stomach pain.
- heart palpitations or chest pains.
- unexplained weakness.
- joint pain.
- unexplained fatigue.
What diseases cause high ferritin levels?
Causes of High Ferritin Blood Levels
- Hemochromatosis.
- Porphyria.
- Rheumatoid arthritis or another ongoing inflammatory problem.
- Liver disease.
- Hyperthyroidism.
- Leukemia.
- Hodgkin’s lymphoma.
- You’ve had several blood transfusions.