Menu Close

How do you calculate carboplatin dosing?

How do you calculate carboplatin dosing?

Carboplatin Dose (mg) = Target area under the curve (AUC mg/mL/min) x (GFR* + 25) *GFR estimated by calculated creatinine clearance using Cockcroft-Gault Equation (see below).

How is AUC chemotherapy calculated?

Background Info

  1. CALVERT FORMULA FOR CARBOPLATIN DOSING: Total Dose (mg) = (target AUC) x (GFR + 25)
  2. AUC = target area under the concentration versus time curve in mg/mL•min.
  3. GFR was measured by 51Cr-EDTA clearance.
  4. Relevant package insert data:

What is AUC for carboplatin?

AUC values of 4 to 6 and 6 to 8 mg/mL. min gave rise to manageable hematological toxicity in previously treated and untreated patients, respectively, and hence target AUC values of 5 and 7 mg/mL min are recommended for single-agent carboplatin in these patient groups.

How are chemo doses calculated?

The majority of cytotoxic chemotherapy doses are individualised for each patient and most commonly calculated based on the patient’s body surface area (BSA), renal function or weight. BSA has been shown to correlate with cardiac output, total blood volume as well as renal function.

What AUC means?

Area under the ROC Curve
AUC stands for “Area under the ROC Curve.” That is, AUC measures the entire two-dimensional area underneath the entire ROC curve (think integral calculus) from (0,0) to (1,1). Figure 5. AUC (Area under the ROC Curve). AUC provides an aggregate measure of performance across all possible classification thresholds.

What is a good AUC score?

between 0.8-0.9
The area under the ROC curve (AUC) results were considered excellent for AUC values between 0.9-1, good for AUC values between 0.8-0.9, fair for AUC values between 0.7-0.8, poor for AUC values between 0.6-0.7 and failed for AUC values between 0.5-0.6.

What factors are used to calculate AUC carboplatin?

The formula is: dose (mg)=AUC (mg ml−1 min)×[GFR (ml/min)+25 (ml/min)]. This formula has proven to be, in both retrospective and prospective studies, a reliable tool to calculate the optimal dose of carboplatin.

What does AUC of 0.8 mean?

In general, an AUC of 0.5 suggests no discrimination (i.e., ability to diagnose patients with and without the disease or condition based on the test), 0.7 to 0.8 is considered acceptable, 0.8 to 0.9 is considered excellent, and more than 0.9 is considered outstanding.

What is AUC of a drug?

In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body.

What is the hardest chemo regimen?

Doxorubicin is considered one of the strongest chemotherapy drugs for breast cancer ever invented. It can kill cancer cells at every point in their life cycle, and it’s used to treat a wide variety of cancers, not just breast cancer. Doxorubicin is also known as “The Red Devil” because it is a clear bright red color.

What is a carboplatin AUC calculator?

This Carboplatin AUC calculator determines the total dosage in mg based on the estimated creatinine clearance and target AUC plus the ideal body weight. There is in depth information on this subject below the form. Other Tools You May Find Useful.

How to calculate carboplatin dose based on Calvert formula?

Female = 45.5 kg + (2.3 * (Height in inches – 60)) ■ Carboplatin dose based on the Calvert formula is: Dosage = Target AUC x (GFR + 25)

How do you dilute 10 mg of carboplatin?

Carboplatin Injection 10 mg/mL is supplied as a Ready To Use (RTU) sterile solution in 5 mL, 15 mL, 45 mL or 60 mL vials. Total content of carboplatin per vial is described in following table: 1 Carboplatin Injection can be further diluted to concentrations as low as 0.5 mg/mL with 5% Dextrose in Water (D5W) or 0.9% Sodium Chloride Injection, USP.

How many milliliters of carboplatin are in a vial?

Carboplatin Injection 10 mg/mL is supplied as a Ready To Use (RTU) sterile solution in 5 mL, 15 mL, 45 mL or 60 mL vials. Total content of carboplatin per vial is described in following table: 1