What does cathepsin K do?
Cathepsin K (CatK) is one of the most potent proteases in lysosomal cysteine proteases family, of which main function is to mediate bone resorption. Currently, CatK is among the most attractive targets for anti-osteoporosis drug development.
Where is cathepsin K expressed?
Cathepsin K is a cysteine protease with type I and type II collagenase activity that is predominantly expressed by osteoclasts. It is secreted into the resorption lacunae below active osteoclasts resulting in type I collagen degradation.
What is cathepsin of lysosome?
Lysosomal cathepsins, which are enclosed in the lysosomes, help to maintain the homeostasis of the cell’s metabolism by participating in the degradation of heterophagic and autophagic material.
Is cathepsin A enzyme?
Cathepsins are protease enzymes, categorized into multiple families. They can be serine protease, cysteine protease, or aspartyl protease [1].
Is cathepsin an enzyme?
Is cathepsin a protease?
Cathepsins are protease enzymes, categorized into multiple families. They can be serine protease, cysteine protease, or aspartyl protease [1]. There were about 11 classes of cathepsins in humans [2], which have now increased to 15, as presented in Table 1 .
Where is cathepsin found?
Cysteine cathepsins like B and L are located in the acidic compartments of cells [3]. The protein encoded by SNX10 (Sorting Nexin 10) plays an essential role in endosomal trafficking and chaperone-mediated autophagy [15].
Which of the following is an inhibitor of apoptosis?
Which of the following is an inhibitor of apoptosis? Explanation: Caspases are the effectors of apoptosis. IAP binds to the caspases thus preventing apoptosis from taking place. Smac and Diablo bind to IAP thus inhibiting it so they are also pro-apoptotic.
Is caspase a protease?
Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death.
What is caspase inhibitor?
Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases).