What is ErbB signaling?
The ErbB receptors signal through Akt, MAPK, and many other pathways to regulate cell proliferation, migration, differentiation, apoptosis, and cell motility. ErbB family members and some of their ligands are often over-expressed, amplified, or mutated in many forms of cancer, making them important therapeutic targets.
Is ERBB2 a tumor suppressor?
ErbB2-intronic MicroRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling | Cell Death & Disease.
What is ERBB2 gene?
ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2, also known as HER2 and neu) is a gene that encodes for the receptor tyrosine-protein kinase erbB-2. ERBB2 has been found to be amplified with an increased copy number in several cancers (PMID: 20185938).
What do Erbb receptors do?
The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions, including cell growth and survival. They signal through phosphorylated tyrosines on their intracellular domains. Activation of these receptors leads to this phosphorylation and to subsequent intracellular signaling.
Is Erbb the same as EGFR?
Family members. v-ErbBs are homologous to EGFR, but lack sequences within the ligand binding ectodomain.
Is HER2 same as ERBB2?
The HER2 is the legacy gene symbol for ERBB2 and may be more commonly used by the community; HER2 is also commonly used to describe the protein encoded by the ERBB2 gene. One unique feature of HER2 compared with the other receptors in the HER family is the absence of a known ligand.
Is HER2 a tumor suppressor gene?
In vivo studies show that these HER2/neu repressors can act therapeutically as tumor suppressor genes for tumors that overexpress HER2/neu. These preclinical studies clearly indicate that transcriptional repressors that downregulate HER2/neu can be effective regimens for cancer treatment in a gene therapy format.
Is ErbB an oncogene?
The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are homologous: erythroblastic leukemia viral oncogene.
What type of receptor is ErbB?
receptor tyrosine kinases
The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions, including cell growth and survival. They signal through phosphorylated tyrosines on their intracellular domains. Activation of these receptors leads to this phosphorylation and to subsequent intracellular signaling.
What do ErbB receptors do?
What are the ErbB growth factors and which ErbB receptors they bind to?
Eleven different EGF-like growth factors, which directly activate ErbB receptors, have been identified: EGF, transforming growth factor alpha (TGF-α), amphiregulin, heparin-binding-EGF (HB-EGF), epiregulin, betacellulin, epigen, and the neuregulins (NRG-1, NRG-2, NRG-3, NRG-4) also known as heregulins.
What does ERBB2 amplification mean?
ERBB2 Amplification is a predictive biomarker for use of trastuzumab, lapatinib, pertuzumab, ado-trastuzumab emtansine, aromatase inhibitor, fam-trastuzumab deruxtecan, capecitabine, endocrine therapy, cisplatin, docetaxel, paclitaxel, carboplatin, fluorouracil, margetuximab, neratinib, pembrolizumab, pertuzumab/ …
What is the difference between HER2 and EGFR?
HER2 is a member of the human epidermal growth factor receptor (EGFR) family, which induces the activation of signalling pathways that promote cell proliferation and survival by dimerization with other EGFR family members.
How does HER2 contribute to oncogene?
The HER2 gene encodes the receptor tyrosine kinase HER2 and is often over-expressed or amplified in breast cancer. Up-regulation of HER2 contributes to tumor progression. Many aspects of tumor growth are favorably affected through activation of HER2 signaling.
Why is HER2 an oncogene?
HER2 is a membrane tyrosine kinase and oncogene that is overexpressed and gene amplified in about 20% of breast cancers. When activated it provides the cell with potent proliferative and anti-apoptosis signals and it is the major driver of tumor development and progression for this subset of breast cancer.