What is the diagnosis of dengue fever?
Nucleic acid amplification tests (NAATs) For patients with suspected dengue virus disease, NAATs are the preferred method of laboratory diagnosis. NAATs should be performed on serum specimens collected 7 days or less after symptom onset.
What are the effects of disease dengue?
The most common symptom of dengue is fever with any of the following: Nausea, vomiting. Rash. Aches and pains (eye pain, typically behind the eyes, muscle, joint, or bone pain)
What is the gold standard for dengue diagnosis?
The World Health Organization (WHO) 2009 guidelines identify three diagnostic tests as gold standards for dengue diagnosis: viral isolation and identification, nucleotide detection, and serological tests for IgM or IgG seroconversion.
Does dengue have after effects?
Muscle pain, bone pain, joint pain, rashes, high fever, throbbing headache, vomiting and nausea are the common symptoms of dengue. Dengue can cause severe health issues as it breaks down the immunity system and hence the person has to suffer issues post-recovery as well.
What causes dengue fever?
Dengue is a viral infection transmitted to humans through the bite of infected mosquitoes. The primary vectors that transmit the disease are Aedes aegypti mosquitoes and, to a lesser extent, Ae. albopictus. The virus responsible for causing dengue, is called dengue virus (DENV).
Does dengue stay in your system forever?
There is no human-to-human dengue fever transmission. Once a mosquito is infected, it remains infected for its life span.
Does dengue affect the brain?
The Dengue virus infection of the CNS has been confirmed by the detection of viral antigens and DENV RNA in brain tissue and cerebrospinal fluid (CSF) samples. The entry of the virus into the brain seems to occur through infiltrates of infected macrophages 10. Miagostovich MP, Ramos RG, Nicol AF, et al.
WHO dengue diagnosis criteria?
To meet a case definition of DHF, all 4 criteria are required: (1) fever, (2) hemorrhagic manifestations, (3) thrombocytopenia (platelet count, ≤100000 platelets/mm3), and (4) evidence of plasma leakage. Diagnosis of DHF does not require laboratory support.
What is the difference between dengue and dengue fever?
DHF is a more severe form of dengue. Initial symptoms are the same as dengue but are followed by bleeding problems such as easy bruising, skin hemorrhages, bleeding from the nose or gums, and possible bleeding of the internal organs. DHF is very rare.
WHO dengue latest guidelines?
Dengue should be suspected when a high fever (40°C/104°F) is accompanied by 2 of the following symptoms during the febrile phase (2-7 days): severe headache. pain behind the eyes. muscle and joint pains.
WHO dengue guideline 2009?
The 2009 WHO guidelines distinguish between severe and non-severe dengue. Severe dengue is defined by the occurrence of plasma leakage and/or fluid accumulation leading to shock or respiratory distress; and/or severe bleeding; and/or severe organ impairment.
How does the body react to dengue?
The spread of the dengue virus results in viremia, which is a high level of the virus in the bloodstream. To fight the infection, the immune system produces antibodies to neutralize the dengue viral particles, and the complement system is activated to help the antibodies and white blood cells remove the virus.
What is Stage 4 dengue?
Dengue begins abruptly after a typical incubation period of 5–7 days, and the course follows 3 phases: febrile, critical, and convalescent.