What is the difference between Type 1 and Type 2 statins?
Type 1 statins (e.g., simvastatin) exhibit binding via a decalin ring structure, and type 2 statins (e.g., rosuvastatin, atorvastatin, fluvastatin) exhibit additional binding via their fluorophenyl group.
When do you choose high intensity statins?
Statin Treatment Recommendations Patients ages 20-75 years and LDL-C ≥190 mg/dl, use high-intensity statin without risk assessment. T2DM and age 40-75 years, use moderate-intensity statin and risk estimate to consider high-intensity statins.
Which statin is most prescribed?
Atorvastatin (Lipitor) It is still one of the most commonly prescribed statins, and though not as inexpensive as simvastatin (Zocor), the generic price has continued to drop.
What is the first line statin?
Atorvastatin is the first-line choice of statin treatment.
Which statin is best tolerated?
Among individual statins, simvastatin and pravastatin seem safer and more tolerable than other statins.
At what LDL level is medication required?
Your health care provider may prescribe medicine if: You have already had a heart attack or stroke, or you have peripheral arterial disease. Your LDL cholesterol level is 190 mg/dL or higher.
Is Rosuvastatin a high intensity statin?
Definition of statin intensity was based on the guideline from ACC/AHA. Atorvastatin 40 or 80 mg and rosuvastatin 20 mg were defined as high‐intensity statins, and the other statins were classified as non‐high‐intensity statins.
Which statin is the best choice for which patient?
Statins lower cholesterol levels through inhibition of HMG-CoA reductase. The synthetic and natural statins have essentially equivalent efficacy at improving the lipid profile. However, in patients who do not achieve their LDL goals, atorvastatin and simvastatin may be the best choices for initial therapy.
What is second line to statins?
The top three choices for second-line treatment were adding ezetimibe, switching to strong statins (statin switching), and doubling the original statin dosage (statin doubling). Adding ezetimibe, statin switching, and statin doubling decreased LDL-C levels by 28.2 ± 14.5%, 23.2 ± 24.4%, and 23.5 ± 17.2%, respectively.
Which is best atorvastatin or rosuvastatin?
Efficacy. At the end of the titration-to-goal period, rosuvastatin was significantly more effective than atorvastatin on the primary efficacy measure, reducing LDL-C by 52% compared with 46% in the atorvastatin group (p < 0.0001) (table 2).