What is dispersion technique?
Dispersion is a technique resulting in a substance dispersed or embedded in another molecule or continuous phase. A dispersion can be classified in a number of ways according to the size and the state of dispersed matter.
What is SDD formulation?
As the name suggests, SDDs are obtained by dissolving drug and polymer in an organic solvent and then spray drying the solution. The formulation and process conditions are chosen so that the solvent quickly evaporates from the droplets, allowing insufficient time for phase separation or crystallization.
What is solvent dispersion method?
In this method, both drug and carrier are dissolved in organic solvent. After entire dissolution, the solvent is evaporated. The solid mass is ground, sieved and dried. Ex. Solid dispersion of furosemide with eudragits was prepared by solvent evaporation method (Rasenack et al., 2003).
What is dispersion in pharma?
Pharmaceutical dispersions are systems where one substance is dispersed within another substance.
What is SDD Pharma?
Spray-Dried Dispersion (SDD), Drug Product Manufacturing | BioDuro.
What is spray drying process?
The spray drying process involves the atomization of a solution, slurry, or emulsion containing one or more components of the desired product into droplets by spraying followed by the rapid evaporation of the sprayed droplets into solid powder by hot air at a certain temperature and pressure.
What is dispersion in pharmacy?
Pharmaceutical dispersions are systems where one substance is dispersed within another substance. In this sense, these would include homogenous molecular dispersions—the true solutions discussed in Chapter 3.
What is the difference between dispersion and suspension?
Dispersions consist of a continuous and dispersed phase. The classification of dispersions is based on the particle sizes and homogeneity of the mixture. The main dispersion categories are suspensions, and colloids. Suspensions are heterogeneous mixtures that contain larger particles than solutions.
What is solid dispersion?
The term solid dispersion refers to the dispersion of one or more active ingredients in a hydrophilic inert carrier matrix at molecular level. It is prepared by the melt (fusion) method and solvent evaporation technique. However, the process is individualized depending on the interaction between drug and carrier.
What are the classification of dispersion?
There are two types of dispersion systems, Molecular Dispersions and Coarse Dispersions. Molecular dispersions are dedicated solutions to a solute phase in the solvent. The dispersed phase is homogeneously distributed in the dispersion medium.
What is dispersion in pharmaceuticals?
What gas is used in spray drying?
Air is the heated drying medium; however, if the liquid is a flammable solvent such as ethanol or the product is oxygen-sensitive then nitrogen is used.
What is the difference between spray drying and freeze drying?
Product temperatures in freeze drying are generally below 0°C in primary drying and 20-30°C during secondary drying, whereas product temperatures in spray drying are regularly above 80°C.