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What is the cause of Granulocytopenia?

What is the cause of Granulocytopenia?

The most common causes of granulocytopenia are chemotherapy treatments for cancer, adverse drug reactions, autoimmune disorders that affect the bone marrow, and bone marrow failure.

What is Granulocytopenia?

Listen to pronunciation. (GRAN-yoo-loh-SY-toh-PEE-nee-uh) A condition in which there is a lower-than-normal number of granulocytes (a type of white blood cell).

How do you detect agranulocytosis?

To diagnose agranulocytosis, your provider will order a blood test. This test, called a complete blood count (CBC), checks neutrophil levels in your blood. Your healthcare provider may also take a sample of your bone marrow to evaluate how your body produces white blood cells.

What drugs cause granulocytopenia?


Drug classes Drugs
Antipsychotic drugs Chlorpromazine, clozapine, levomepromazine, olanzapine, perazine, quetiapine, thioridazine, ziprasidone
Antirheumatic drugs Auranofin, infliximab, penicillamine, sulfasalazine
Thyrostatic drugs Carbimazole, thiamazole, Propylthiouracil

What is lymphocytosis granulocytopenia?

A rare disorder, lymphocytopenia (lymphopenia) is a deficiency of circulating lymphocytes (leukocytes produced mainly in lymph nodes). Causes. Granulocytopenia may result from diminished production of granulocytes in bone marrow, increased peripheral destruction of granulocytes, or greater use of granulocytes.

What is the difference between agranulocytosis and granulocytopenia?

Granulocytopenia or, as it is also called, agranulocytosis results in a syndrome of frequent chronic bacterial infections of the skin, lungs, throat etc. Although “agranulocytosis” literally means no granulocytes, there may, in fact, be some granulocytes but too few of them, i.e. granulocytopenia.

What is leukopenia granulocytopenia?

It is almost always due to a decrease in one subset of white blood cells. It can be due to: Granulocytopenia: A general term referring to all granulocytes, including neutrophils, monocytes, eosinophils, and basophils. Neutropenia: A reduction in the number of neutrophils.

What is the most common cause of agranulocytosis?

Acquired agranulocytosis is almost invariably caused by exposure to drugs and/or chemicals. Any chemical or drug that depresses the activity of the bone marrow may cause agranulocytosis. Some drugs cause this reaction in anyone given large enough doses.

What is leukopenia Granulocytopenia?

How serious is leukopenia?

Because leukopenia involves low levels of infection-fighting immune cells, it can cause some potentially serious complications if left untreated. Some of the complications of leukopenia include: needing to delay cancer treatment because of a mild infection.

How quickly does agranulocytosis occur?

Agranulocytosis usually occurs within the first 2–3 months of treatment (2); however, certain cases have demonstrated that agranulocytosis may occur following long-term treatment (3).

Does MS cause low white blood cell count?

Multiple sclerosis patients are at risk of developing lymphopenia, or abnormally low levels of immune defense white blood cells, called lymphocytes, according to a study that investigated lymphocyte counts in people with relapsing MS both before and after the start of treatment.

How do you stop agranulocytosis?

The only way to prevent agranulocytosis is to avoid the drugs that may cause it. If you need to take a drug known to trigger the condition, you’ll need to get regular blood tests to check your neutrophil levels. Your doctor may advise you to stop taking the drug if you have lowered neutrophil counts.

Which medication has the highest risk of agranulocytosis?

The drug most strongly associated with a risk of agranulocytosis was ticlopidine hydrochloride with an odds ratio (OR) of 103.23 (95% confidence interval [CI], 12.73-837.44), followed by calcium dobesilate (OR, 77.84 [95% CI, 4.50-1346.20]), antithyroid drugs (OR, 52.75 [95% CI, 5.82-478.03]), dipyrone (metamizole …