What is the use of Pargyline?
Pargyline is a monoamine oxidase (MAO) inhibitor that is used clinically in the treatment of hypertension. This drug is metabolized by cytochrome P450 (CYP450), specifically CYP2E1 to yield propiolaldehyde (Moridani et al., 2001).
What class of drug is Pargyline?
Pargyline is a monoamine oxidase B (MAO-B) inhibitor with antihypertensive properties.
What do MAOIs do?
Antidepressants such as MAOIs ease depression by affecting chemical messengers (neurotransmitters) used to communicate between brain cells. Like most antidepressants, MAOIs work by ultimately effecting changes in the brain chemistry that are operational in depression.
What is the mechanism of action of selegiline?
The action of selegiline is to inhibit monoamine oxidase (MAO) type B (and other MAOs at higher doses). The proposed mechanism of action is to inhibit the metabolism of dopamine in the CNS.
How long does moclobemide stay in your system?
The MAO inhibition of moclobemide lasts about 8–10 hours and wears off completely by 24 hours after dosing. The inhibition of MAO-A by moclobemide is 10 times more potent than the irreversible MAOIs phenelzine and approximately equivalent to tranylcypromine and isocarboxazid.
How does MAOI cause hypertensive crisis?
Since MAOIs inhibit monoamine oxidase, they decrease the breakdown of tyramine from ingested food, thus increasing the level of tyramine in the body. Excessive tyramine can elevate blood pressure and cause a hypertensive crisis.
How do MAOIs cause hypotension?
Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Md. A number of investigators have speculated that MA0 inhibitors elicit orthostatic hypotension by interfering with transmission in sympathetic ganglia.
How is MAOI hypertensive crisis treated?
Intravenous benzodiazepines are useful for agitation and seizure control. They also may help control the hypertension. Hospital admission is recommended in a patient with a tyramine reaction if symptoms do not resolve within 6 hours of onset or if the episode was an intentional MAOI overdose.
Does selegiline lower blood pressure?
Selegiline therapy was associated with orthostatic hypotension on tilting at 10 minutes and lesser hypotension on tilting for 2 minutes and standing. On tilting for 10 minutes, six patients on selegiline developed symptomatic hypotension and in five the blood pressure fell to below 100 mm Hg.
What are the side effects of selegiline?
Selegiline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- dry mouth.
- stomach pain.
- difficulty swallowing.
Does moclobemide increase blood pressure?
When taken with certain drinks or other medicines, moclobemide and other monoamine oxidase inhibitors can cause very dangerous reactions, such as sudden high blood pressure (also called hypertensive crisis).
Does moclobemide cause hypertensive crisis?
Unlike irreversible MAO-inhibitors, moclobemide has a negligible propensity to induce hypertensive crisis after ingestion of tyramine-rich food (“cheese-reaction”). Therefore, dietary restrictions are not as strict.
Can imipramine cause high blood pressure?
It was demonstrated that imipramine had no significant effect on sitting or standing diastolic or systolic blood pressure. Although there was a trend toward a systolic blood pressure drop with positional change, it did not reach statistical significance.
Can anticholinergics cause hypertension?
High blood pressure—The decongestant and anticholinergic in this medicine may cause the blood pressure to increase and may also speed up the heart rate.
How does tyramine increase BP?
Tyramine can trigger nerve cells to release norepinephrine, a hormone that increases blood pressure and heart rate. People who already have high blood pressure need to be careful when consuming foods with high tyramine levels. The most common signs of a sudden increase in blood pressure are: Headaches.