Is Precedex approved for pediatrics?
It has sedative as well as analgesic properties and was approved for use by the U.S. Food and Drug Administration (FDA) in December 1999. Although it is heavily used in practice, it still is not specifically approved for pediatric use.
Is dexmedetomidine FDA approved for children?
As denoted on the latest product information from Pfizer, which was revised in March 2018, dexmedetomidine (Precedex®) is not recommended for use in children1.
How do you calculate Precedex drip?
Precedex Injection, 200 mcg/2 mL (100 mcg/mL) To prepare the infusion, withdraw 2 mL of Precedex Injection, and add to 48 mL of 0.9% sodium chloride injection to a total of 50 mL. Shake gently to mix well.
When should you not use Precedex?
Dexmedetomidine should be avoided in patients with advanced heart block and ventricular dysfunction. Doses of the drug should be reduced in patients with hepatic impairment because the drug is highly metabolized by the liver.
How long does it take Precedex to wear off?
Maximum Duration: After extubation, the dose of Precedex should be reduced by half. The mean time of continued infusion is approximately 6.6 hours.
Why is Precedex used in ICU?
Background. Dexmedetomidine produces sedation while maintaining a degree of arousability and may reduce the duration of mechanical ventilation and delirium among patients in the intensive care unit (ICU).
Can Precedex be stopped abruptly?
The manufacturer product information states that the abrupt cessation of dexmedetomidine could potentially result in withdrawal symptoms similar to those seen with clonidine (i.e., agitation, irritability, rebound hypertension). At least one case of neurological adverse events has been reported.
What is the dosing for Precedex?
Precedex dosing should be individualized and titrated to desired clinical response. Precedex is not indicated for infusions lasting longer than 24 hours. Precedex should be administered using a controlled infusion device. For adult patients: a loading infusion of one mcg/kg over 10 minutes.
How do you administer Precedex infusion?
Are there any pediatric indications for Precedex™ (dexmedetomidine)?
There are no pediatric indications. 5 Background Drug Information, continued Precedex™(dexmedetomidine) Contraindications(section 4) None Warnings and Precautions (section 5) • Drug Administration – only administered in intensive care or operating room setting. • Hypotension, Bradycardia and Sinus Arrest • Transient Hypertension
What is the maximum amount of prednisone for a child?
Infants and Children 6 months to 12 years 1 to 4 mcg/kg (Max: 200 mcg) intranasally (divided and given in both nostrils) as a single dose 30 to 60 minutes before the nonpainful procedure. Infants 1 to 5 months 2 to 3 mcg/kg intranasally (divided and given in both nostrils) as a single dose 30 minutes before the nonpainful procedure.