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How do dendrimers work?

How do dendrimers work?

In the different methods, dendrimer grows outward from a multifunctional core molecule. The core molecule reacts with monomer molecules containing one reactive and two dormant groups, giving the first-generation dendrimer. Then, the new periphery of the molecule is activated for reactions with more monomers.

What are dendrimers in nanotechnology?

Abstract. Dendrimers represent a class of novel polymers having unique molecular architectures characterized by their well-defined structure, with a high degree of molecular uniformity, low polydispersity and properties that make them attractive materials for the development of nanomedicines.

What is the meaning of dendrimers?

Dendrimers are highly ordered, branched polymeric molecules. Synonymous terms for dendrimer include arborols and cascade molecules. Typically, dendrimers are symmetric about the core, and often adopt a spherical three-dimensional morphology. The word dendron is also encountered frequently.

Are dendrimers polymeric nanoparticles?

In addition, dendrimers are well-defined nano-sized symmetric polymeric molecules. In this review, we provide an analysis of the use of dendrimers modified with aptamers as nonviral vectors to specifically target tumor cells.

What is the meaning of Pamam?

Poly(amidoamine), or PAMAM, is a class of dendrimer which is made of repetitively branched subunits of amide and amine functionality.

What are generations of dendrimers?

Structure of PAMAM Dendrimers: Generations 1 through 11

generation Rg RN
1 7.46 10.36
2 9.17 11.61
3 11.23 12.91
4 14.5 16.81

What are PAMAM dendrimers?

PAMAM dendrimers are a family of highly branched and mono-disperse synthetic macromolecules with well-defined structures and compositions. Synthesis of these nanocarriers can be carried out through the divergent route.

Can dendrimers be used for gene therapy in vivo?

The mechanism of gene transfer using dendrimers and some functionalization strategies for overcoming the extracellular and intracellular barriers for efficient delivery of genetic material are discussed. Finally, the use of dendrimers for the delivery of gene therapy in vivo is summarized. 1. Introduction

Why are dendrimers used for transfection?

These compounds show better transfection efficiency and lower toxicity compared to other branched or linear polymers. Also, dendrimers have been shown to have improved serum stability, and allow controlled release of encapsulated genes with good cell and tissue uptake.

What are the advantages of PAMAM dendrimers?

PAMAM dendrimers are suitable carriers in gene delivery because of their advantages, such as water solubility, nonimmunogenicity, acceptable biodegradation, biocompatibility, spherical structure, and minimal nonspecific blood-protein binding [61], [84].

What is the shape of a dendrimer?

Dendrimers are spherical and highly branched macromolecules, which have been studied as a type of nonviral gene carrier. They are highly symmetric and nano-sized macromolecules (in the range of 1–100 nm) with a well-defined structure, surface charge, and molecular size.