Which serious adverse effects can occur in a patient taking eplerenone?
Serious side effects
- dehydration.
- fatigue.
- swelling of your legs.
- confusion.
- decrease in urination.
- Hyperkalemia (high potassium levels in your blood. Symptoms can include: muscle weakness. tiredness. irregular heartbeat. tingling. nausea.
What drugs should not be taken with eplerenone?
Tell your doctor if you are taking any of these medicines before starting eplerenone:
- high blood pressure medicines like ramipril, enalapril, losartan or candesartan.
- tacrolimus or ciclosporin, used to treat skin conditions such as psoriasis or eczema.
- trimethoprim, an antibiotic for UTIs and other infections.
What is a common side effect of eplerenone spironolactone )?
nausea, cough or flu-like symptoms (such as fever, chills, body aches, unusual tiredness), vaginal bleeding, or. breast swelling or tenderness.
Does eplerenone cause hyperkalemia?
The most common side effect of eplerenone was hyperkalemia (9).
Does eplerenone cause hyponatremia?
Patients assigned to eplerenone had a lower mean serum sodium over the follow-up (140 vs 141 mmol/L; p < 0.0001) and more often developed hyponatremia episodes (15 vs 11% p = 0.0001) and less often hypernatremia episodes (22 vs. 26% p = 0.0003).
Does eplerenone affect heart rate?
Results: High resting heart rate of 80 bpm and above predisposed patients to greater risk of all outcomes in the trial, regardless of treatment allocation. The beneficial effects of eplerenone were observed across all categories of heart rate.
Is eplerenone a potassium-sparing diuretic?
Synopsis: Eplerenone, a potassium-sparing diuretic similar to spironolactone, selectively blocks aldosterone to lower blood pressure. However, its safety profile is improved over spironolactone because of reduced progesterone and androgen-receptor effects.
Does eplerenone cause hypernatremia?
Can you take spironolactone with eplerenone?
Interactions between your drugs Using eplerenone together with spironolactone is not recommended. Combining these medications may significantly increase potassium levels in the blood.
Why is eplerenone better than spironolactone?
Pharmacological differences between spironolactone and eplerenone include lower affinity of eplerenone for progesterone, androgen, and glucocorticoid receptors; more consistently demonstrated nongenomic properties for eplerenone; and the presence of long-acting metabolites for spironolactone.
Why is eplerenone used in heart failure?
In conclusion, our study showed that, as compared with placebo, eplerenone added to recommended therapy for systolic heart failure in patients with mild symptoms was associated with a reduction in the rate of death from a cardiovascular cause or hospitalization for heart failure.
What are the side effects of eplerenone?
Commonly reported side effects of eplerenone include: cough, diarrhea, fatigue, and flu-like symptoms. See below for a comprehensive list of adverse effects. For the Consumer. Along with its needed effects, eplerenone may cause some unwanted effects.
How does eplerenone interact with lithium?
Through its effects on aldosterone, eplerenone promotes natruresis and therefore may stimulate a reflex increase in lithium and sodium reabsorption in the kidney. Therefore, if eplerenone is administered concomitantly with lithium, serum lithium levels should be monitored frequently.
What are the contraindications for eplerenone?
Increased eplerenone concentrations may lead to a risk of developing hyperkalemia and hypotension. Atazanavir; Cobicistat: (Contraindicated) Coadministration of atazanavir and eplerenone is contraindicated. Atazanavir potently inhibits the hepatic CYP3A4 isoenzyme and can increase the serum concentrations of eplerenone.
Is eplerenone safe for patients with hepatic impairment?
Although eplerenone was not found to have any associated adverse effects in patients with mild to moderate hepatic impairment, it should be used cautiously in patients with severe hepatic disease; the use of eplerenone has not been evaluated in patients with severe hepatic impairment.