Does interferon cause anxiety?
These effects can occur either shortly after beginning IFN therapy or later as a result of continued treatment. Studies have reported the incidence of later side effects, which include symptoms of depression, anxiety, and occasional suicidal ideation, to be from 0% to 70%.
Does Pegasys cause depression?
This drug may cause you to develop serious mental/mood changes that may get worse during treatment or after your last dose. Tell your doctor right away if you have symptoms such as confusion, depression, suicidal thoughts, unusual irritability, or aggressive behavior.
Can interferon cause depression?
Neuropsychiatric adverse effects of interferons The neuropsychiatric adverse effects of IFNs include depression, irritability, anxiety, agitation, loss of appetite, fatigue, sleep disturbance, and impaired cognition; quality of life and functional abilities are consequently compromised.
Does interferon cause insomnia?
Although neuropsychiatric symptoms of IFN vary, affective disorders such as depression are most frequent, followed by cognitive disorders including delirium. Others include insomnia, anxiety, irritability, mania, delusion, hallucina- tion, and change to aggressive personality.
Why does interferon cause depression?
IFN therapy decreases tetrahydrobiopterin (BH4), a cofactor required for the biosynthesis of serotonin, dopamine, epinephrine, and norepinephrine, thereby predisposing to depression.
Does Rebif cause depression?
Please see Rebif® Prescribing Information and Medication Guide. Rebif can cause serious side effects. Behavioral health problems including depression and suicidal thoughts. Liver problems or worsening of liver problems including liver failure.
Can Rebif cause anxiety?
Get emergency medical help if you have signs of an allergic reaction (hives, itching, anxiety, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Does interferon alfa-2b cause depression in hepatitis C patients?
Results of a recent study (n=14) of patients affected by chronic hepatitis C who received interferon alfa-2b suggests that the development of the interferon alfa-induced depressive symptoms may arise through depletion of central and peripheral 5-HT and reduction of tryptophan plasma levels.
What is interferon-alpha (IFN-alpha)?
Aim: Interferon-alpha (IFN-alpha) has been extensively explored for its efficacy in various disease conditions and is currently used as a standard treatment in several of these. Its use is accompanied by a wide variety of possible side effects.
What are the signs and symptoms of immunoglobulin A (IFN) toxicity?
Taken together, occurrence of flu-like symptoms, hematological toxicity, elevated transaminases, nausea, fatigue, and psychiatric sequelae are the most frequently encountered. Although insight in the mechanisms accounting for IFN-alpha-related toxicities has improved in recent years, much remains to be elucidated.