What is the medication classification of tolterodine?
Tolterodine belongs to the group of medicines called antispasmodics. It helps decrease muscle spasms of the bladder and the frequent urge to urinate caused by these spasms. This medicine is available only with your doctor’s prescription.
Is tolterodine an anticholinergic?
Tolterodine tartrate is marketed as a bladder-selective anticholinergic drug that is reported to be free of significant cognitive adverse effects.
What is the mechanism of action of tolterodine?
Mechanism Of Action Tolterodine acts as a competitive antagonist of acetylcholine at postganglionic muscarinic receptors. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors.
What drugs interact with dextromethorphan?
Is tolterodine an alpha blocker?
TAMSULOSIN+TOLTERODINE belongs to a group of medications known as ‘antimuscarinic (muscarinic receptor blockers)’ and ‘alpha-blockers’.
What is the brand name of tolterodine?
What Is Tolterodine and How Does It Work? Tolterodine is prescribed for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. Tolterodine is available under the following different brand names: Detrol, and Detrol LA.
Is tolterodine an antimuscarinic?
Tolterodine is a nonsubtype selective antimuscarinic agent recently approved as therapy in patients with overactive bladder with symptoms of urinary frequency, urgency, or urge incontinence. It acts by muscarinic receptor blockade in the bladder wall and detrusor muscle.
What are antimuscarinic drugs?
Abstract. Antimuscarinic agents are the predominant pharmacological treatment for patients with overactive bladder (OAB). These drugs are thought to act primarily through antagonism at muscarinic M3 receptors located at neuromuscular junctions in the human bladder detrusor muscle.
What is the medicine tolterodine used for?
This medication is used to treat an overactive bladder. By relaxing the muscles in the bladder, tolterodine improves your ability to control your urination. It helps to reduce leaking of urine, feelings of needing to urinate right away, and frequent trips to the bathroom.
Who should avoid dextromethorphan?
You should not use dextromethorphan if you are allergic to it. Ask a doctor or pharmacist if this medicine is safe to use if you have any medical conditions. Dextromethorphan should not be given to a child younger than 12 years old. Ask a doctor before using this medicine if you are pregnant or breast-feeding.
Is doxazosin an anticholinergic?
Case series evaluated anticholinergic agents (propiverine or tolterodine), either alone or combined with an α-blocker (doxazosin, terazosin or unspecified). The duration of case series ranged from 1 to 7.8 months.
Which classification does calcium gluconate belong?
Calcium Gluconate belongs to a class of drugs called Antidotes, Other; Calcium Salts.
What are cholinergic agonist drugs?
Cholinergic agonists are drugs that mimic the action of the neurotransmitter acetylcholine. The parasympathetic nervous system controls various organ and gland functions at rest, including digestion, defecation, lacrimation, salivation, and urination, and primarily uses acetylcholine as its main neurotransmitter.
What drugs are muscarinic antagonists?
Commonly used muscarinic antagonists include atropine, scopolamine, glycopyrrolate, and ipratropium bromide. Administering muscarinic antagonists is a must when the effect of muscle relaxants is antagonized by acetylcholinesterase inhibitors, lest profound bradycardia, heart block, and asystole ensue.
What are the examples of antimuscarinic?
- 3.1. Oxybutynin. Oxybutynin is the first antimuscarinic used for the treatment of OAB.
- 3.1. Tolterodine. Tolderodine is a widely prescribed antimuscarinic and, it was the first specifically developed to treat OAB.
- 3.1.3. Propiverine.
- 3.1. Darifenacin.
- 3.1. Solifenacin.
What kind of drug is dextromethorphan?
Dextromethorphan (DXM) is an over-the-counter (OTC) cough suppressant commonly found in cold medications. DXM is often abused in high doses by adolescents to generate euphoria and visual and auditory hallucinations.
What class of drug is dextromethorphan?
Dextromethorphan. It is sold in syrup, tablet, spray, and lozenge forms. It is in the morphinan class of medications with sedative, dissociative, and stimulant properties (at lower doses). In its pure form, dextromethorphan occurs as a white powder.
What is the generic name for tolterodine?
Tolterodine Generic name: tolterodine (tol TER oh deen) Brand name: Detrol, Detrol LA Dosage forms: oral capsule, extended release (2 mg; 4 mg); oral tablet (1 mg; 2 mg)
What is the pharmacokinetics of dextromethorphan hydrobromide?
Pharmacokinetics. The duration of action after oral administration is about three to eight hours for dextromethorphan hydrobromide, and 10 to 12 hours for dextromethorphan polistirex. Around one in 10 of the Caucasian population has little or no CYP2D6 enzyme activity, leading to long-lived high drug levels.
Is tolterodine a target for muscarinic receptors?
Both tolterodine and the 5-hydroxymethyl metabolite exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. Tolterodine has a pronounced effect on bladder function.