What is beta-cyclodextrin?
β-Cyclodextrin, a cyclic oligosaccharide consisting of seven glucose units joined as α-(1 → 4) isomers, is nontoxic, edible, nonhygroscopic, chemically stable, and easily separable. It has a cavity at the center of the molecular arrangement and can thus form a stable insoluble inclusion complex with cholesterol.
What is the chemical formula for hydroxypropyl beta-cyclodextrin?
(CODE: 27)
| Average Molecular Formula | C42H70-nO35 · (C3H7O)n |
|---|---|
| Average Formula Weight | 1135.0 + n·(58.1) |
| Possible impurities | Propylene glycol, beta-cyclodextrin, hydroxypropylated linear dextrins |
| Solubility (in 100 cm3 solvent, at 25 °C) | Water: > 33 g Methanol: > 33 g DMF: > 33 g |
What is beta-cyclodextrin used for?
Cyclodextrins, and expecially beta ones, are widely used in the pharmaceutical field for their ability of improving the solubility and the stability of drugs by complex formation at the solid state.
What is HP β CD?
2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a chemically modified cyclic oligosaccharide produced from starch that is commonly used as an excipient. Although HP-β-CD has been suggested as a potential adjuvant for vaccines, its immunological properties and mechanism of action have yet to be characterized.
Is cyclodextrin a chemical?
Cyclodextrins are sugar molecules bound together in rings of various sizes. Specifically, the sugar units are called glucopyranosides—glucose molecules that exist in the pyranose (six-membered) ring configuration.
Is beta cyclodextrin soluble in water?
Most chemically modified cyclodextrins are able to achieve a 50% (w/v) concentration in water.
What is cyclodextrin made of?
April 22, 2019. Cyclodextrins consist of sugar molecules (glucopyranosides) arranged in rings. The 6-, 8-, and 10-membered cyclodextrins occur naturally; and until recently the smallest ring to be synthesized contained five glucopyranoside units.
Is beta cyclodextrin natural?
Beta-cyclodextrins (β-CD) are naturally occurring cyclical oligosaccharides able to form solid inclusion complexes with a wide variety of hydrophobic guest molecules [17, 18] , while improving its solubility, increasing its stability in the presence of light, heat, and oxidizing conditions, and decreasing its …
Where can I get cyclodextrin?
Cyclodextrins can be found in nature. Some bacteria (e.g. Bacillus macerans) produce CDs from starch by enzymatic process for their energy storage. This process is mimicked by the industry using cyclodextrin glycosyltransferase enzyme and starch (corn, potato, manioc, etc) as raw material.
What is 2-hydroxypropyl-β-cyclodextrin in?
2-Hydroxypropyl-β-cyclodextrin (HP-β-CyD) is a cyclic oligosaccharide that is widely used as an enabling excipient in pharmaceutical formulations, but also as a cholesterol modifier.