What is the most sensitive test for HSV?
PCR assays or other NAATs are the most sensitive test currently available to detect HSV in clinical samples. The detection rates of the PCR assays were shown to be 11–71% superior to virus culture [26,41-44].
How accurate are HSV serology tests?
The IgG test is about 94% accurate in detecting the infection. About 19% of the time, its results are false positive (that is, the test is positive for herpes infection when the person does not have herpes). By contrast, the herpes IgM antibodies tests give almost 50% false-negative results.
How sensitive is HSV culture?
HSV Culture Viral culture is the gold standard for diagnosis of HSV infection, and has a sensitivity of 50% and a specificity of nearly 100%.
What is HSV serology test?
Herpes serology; HSV blood test. Serum herpes simplex antibodies is a blood test that looks for antibodies to the herpes simplex virus (HSV), including HSV-1 and HSV-2. HSV-1 most often causes cold sores (oral herpes).
What is a high HSV-1 index value?
0.80 – 0.99: Equivocal-Repeat in 10-14 days may be helpful. Greater than 0.99: Positive – May indicate a current or previous HSV infection. 0.90 – 1.09 IV: Equivocal – Repeat testing in 10-14 days may be helpful. Greater than 1.09: Positive – May indicate a current or recent infection.
How accurate is herpes simplex virus (HSV-1) IgG detection?
When compared to PCR results HSV-1 IgG detection in both primary and recurrent genital herpes diagnosis had poor specificity, positive predictive value, and sensitivity. Whereas, HSV-2 serology had a sensitivity of 13.33% and 73.33% in primary and recurrent genital herpes and specificity of 83.33% and 85.71%, respectively.
Which HSV-2 serologic assay is the best?
Our comparison of HSV-2 serologic assays from samples of a community-based HSV-2 serosurveillance study in Kampala, Uganda indicate that as a single assay, Kalon had the best overall sensitivity and specificity .
What are the different types of herpes virus serology?
Two “gold standard” type-specific serologic assays, Western Blot (“WB”) and monoclonal antibody inhibition assays [18, 19], have been developed based on detection of antibody response to the type-specific gG herpes virus glycoprotein.
What is the difference between HSV-1 IgG and HSV2 IgG?
HSV-2 IgG detection helps in strengthening the diagnosis of recurrent HSV-2 disease, whereas the absence of HSV-2 IgG antibody helps in excluding genital herpes as a likely cause of recurrent genital ulceration. However, detection of HSV-1 IgG antibody may not be useful for diagnosis in patients of …