What is the antidote for Dilantin?
There is no antidote, and there is no evidence that any method of gastrointestinal decontamination or enhanced elimination improves outcome. Activated charcoal should be considered if the patient presents early; however, the role of multiple-dose activated charcoal is controversial.
How much phenytoin is lethal?
Fatal cases of single phenytoin ingestions typically involve serum concentrations of greater than 125 mg/L.
How much Dilantin is an overdose?
Signs and symptoms of phenytoin toxicity typically correspond to the serum level, and progress from occasional mild nystagmus at 10-20 mcg/mL (the therapeutic range) to coma and seizures at levels above 50 mcg/mL (see Presentation and Workup).
What can happen if you administer IV Dilantin too fast?
The most notable signs of toxicity associated with the intravenous use of this drug are cardiovascular collapse and/or central nervous system depression. Hypotension does occur when the drug is administered rapidly by the intravenous route.
What happens if you take too much phenytoin?
If you take too much: If you take too much of this drug, you may have the following symptoms: uncontrolled eye movements. problems with muscle coordination. slurred speech.
What are the symptoms of Dilantin toxicity?
Symptoms
- Coma.
- Confusion.
- Staggering gait or walk (early sign)
- Unsteadiness, uncoordinated movements (early sign)
- Involuntary, jerky, repeated movement of the eyeballs called nystagmus (early sign)
- Seizures.
- Tremor (uncontrollable, repeated shaking of the arms or legs)
- Sleepiness.
What are the symptoms of DILANTIN toxicity?
Can Dilantin cause delirium?
Serum levels of phenytoin sustained above the therapeutic range may produce confusional states referred to as “delirium,” “psychosis,” or “encephalopathy,” or rarely irreversible cerebellar dysfunction and/or cerebellar atrophy.