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Why is nilotinib better than imatinib?

Why is nilotinib better than imatinib?

First, nilotinib is a more potent and selective BCR-ABL inhibitor than imatinib. Second, within the first year of therapy, the number of progression events was significantly lower in both nilotinib groups than in the imatinib group, a phenomenon that has not been observed for the 800-mg dose of imatinib.

Is nilotinib a chemotherapy drug?

Tasigna (nilotinib) is an oral chemotherapy drug manufactured by Novartis. The U.S. Food and Drug Administration approved it in 2007. Doctors prescribe the drug to treat a specific type of blood cancer called Philadelphia chromosome-positive chronic myeloid leukemia.

Is nilotinib better than dasatinib?

Conclusions: The CEA based on real-world comparative evidence suggests that second-line nilotinib is associated with better life expectancy, quality of life, and lower cost when compared with dasatinib, among patients with Ph+ CML-CP who are resistant or intolerant to imatinib.

What is the medication nilotinib used for?

Nilotinib is used to treat certain types of chronic myeloid leukemia (CML; a type of cancer of the white blood cells) who have recently found to have this condition in adults and children 1 year of age and older.

How long do you take nilotinib?

After taking TASIGNA for at least 3 years, your doctor may determine if you meet certain criteria to be eligible to try stopping treatment with TASIGNA. Your doctor may refer to this as treatment-free remission (TFR).

Does nilotinib cause hair loss?

by Yes, Tasigna can cause hair loss as a side effect. In Tasigna clinical trials 11% to 13% of patients developed alopecia (hair loss). Tasigna is a cancer medicine that is used to treat Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML).

Does nilotinib cause high blood pressure?

Nilotinib can cause high blood pressure in some people. If you already have high blood pressure and are on treatment to control it, tell your doctor. You may need to have regular blood pressure checks.

Does nilotinib cause weight gain?

You may have weight loss or weight gain during Tasigna treatment. In clinical studies, between 1% and 10% of people who took Tasigna had changes in their weight. Rapid and unexplained weight gain may be a symptom of edema (fluid retention) in your body. Other symptoms of edema include shortness of breath and swelling.

What are side effects of nilotinib?

TASIGNA® (nilotinib) capsules may cause side effects in some patients. Some of these side effects are serious and some are more common….Common Side Effects in Adults and Children Include:

  • Nausea.
  • Diarrhea.
  • Rash.
  • Cough.
  • Headache.
  • Constipation.
  • Tiredness.
  • Muscle and joint pain.

What is the difference between nilotinib and imatinib?

Structurally related to imatinib, It is 10–30 fold more potent than imatinib in inhibiting Bcr-Abl tyrosine kinase activity and proliferation of Bcr-Abl expressing cells. Nilotinib was developed by Novartis.

What is nilotinib used to treat?

Nilotinib is used to treat Philadelphia chromosome (Ph+)-positive chronic myelogenous leukaemia. Nilotinib has a number of adverse effects including headache, fatigue, gastrointestinal problems such as nausea, vomiting, diarrhea and constipation, muscle and joint pain, rash and other skin conditions, flu-like symptoms, and reduced blood cell count.

What is the limit of quantification for dasatinib and nilotinib?

The limit of quantification was set at 78.1 ng/mL for imatinib and at 62.5 ng/mL for dasatinib and nilotinib.

Does nilotinib require hoct1?

Also, nilotinib does not require transport into cells by human organic cation transporter 1 (hOCT1), unlike imatinib. 24 Therefore, the action of nilotinib is not impaired in patients with intrinsically low hOCT1 activity.