What are the criteria for lupus diagnosis?
Lupus: Criteria for Diagnosis
- Butterfly (malar) rash on cheeks.
- Rash on face, arms, neck, torso (discoid rash)
- Skin rashes that result from exposure to sunlight or ultraviolet light (photosensitivity)
- Mouth or nasal sores (ulcers), usually painless.
- Joint swelling, stiffness, pain involving two or more joints (arthritis)
What is the hallmark indicator of lupus?
Antinuclear antibody (ANA) autoantibodies, or antibodies produced by the immune system that attack the body’s own cells, are a hallmark of lupus. ANA is a screening test, since almost all patients with lupus have a strongly positive test.
How is lupus activity measured?
The Systemic Lupus Activity Measure-Revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus.
What does an ANA titer of 1 160 mean?
At a dilution of 1:160, only 5 percent of normal individuals have a positive test for ANA. The 1:160 dilution increases the specificity of the ANA test for the diagnosis of autoimmune diseases. ANTINUCLEAR ANTIBODIES TESTING.
What is Sri 4 lupus?
Background The SRI(4) is a composite endpoint used in SLE clinical trials. A post-hoc analysis of two Phase III studies of belimumab1 showed that the achievement of an SRI(4) response at 52 weeks is associated with clinically meaningful benefits, irrespective of the treatment assignments.
What is Selena Sledai score?
The SELENA-SLEDAI consists of 24 items (nine organ systems) that are scored based on presence at the time of visit or in the preceding 10 days. The scoring is additive across items, with a possible total score range of 0 to 105 (higher scores represent greater disease activity).
How is DAS28 score calculated?
DAS28 values were calculated as follows: DAS28 (CRP) = 0.56*√(TJC28) +0.28*√(SJC28)+0.014*GH+0.36*ln(CRP+1)+0.96; DAS28 (ESR) = 0.56*√(TJC28)+0.28*√(SJC28)+0.014*GH+0.70*ln(ESR), where TJC = tender joint count and SJC = swollen joint count.