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Is Fospropofol a prodrug?

Is Fospropofol a prodrug?

Pharmacokinetics. Because fospropofol is a prodrug that requires metabolism to form the active compound propofol, the pharmacokinetics are complex. Onset and recovery are prolonged compared to propofol.

What can I use instead of propofol?

Lidocaine / prilocaine topical.

  • Diprivan.
  • Ketamine.
  • Succinylcholine.
  • Emla.
  • Glycopyrrolate.
  • How long does it take to metabolize propofol?

    Propofol is highly protein-bound in vivo and is metabolised by conjugation in the liver. The half-life of elimination of propofol has been estimated to be between 2 and 24 hours. However, its duration of clinical effect is much shorter, because propofol is rapidly distributed into peripheral tissues.

    Why was Fospropofol discontinued?

    Fospropofol was recently discontinued in the USA; the likely reasons include 1) its delayed onset of effect (peak effect is in 8 minutes with clinical effect in 4–13 minutes) 62 and slower recovery compared to propofol and 2) its significant associated perineal paresthesia and pruritus.

    Is Fospropofol a controlled substance?

    Fospropofol is controlled in schedule IV of the Controlled Substances Act.

    What is the half-life of propofol?

    Half-life: Propofol is bi-phasic, with its initial half-life being relatively quick, around 40 minutes, and its terminal half-life usually being 4 to 7 hours. Context-sensitive half-time may be up to 1 to 3 days after a 10-day infusion. The clinical effect of propofol is much shorter in duration.

    Can nurses give Precedex?

    Registered nurses must complete a moderate sedation inservice and maintain yearly competency. Sedation nurses may then administer midazolam, Fentanyl, Demerol and morphine, under the physician’s direction.

    Does propofol need a filter?

    Propofol injectable emulsion should only be administered through a filter with a pore size of 5 micron or greater unless it has been demonstrated that the filter does not restrict the flow of propofol injectable emulsion and/or cause the breakdown of the emulsion.

    What is the pH of propofol?

    The pKa is 11. The octanol/water partition coefficient for propofol is 6761:1 at a pH of 6 to 8.5.

    What is Fospropofol used for?

    Fospropofol, a new sedative anesthetic, and its utility in the perioperative period Fospropofol is an intravenous sedative-anesthetic agent that is FDA-approved for monitored anesthesia care (MAC) sedation in adult patients undergoing diagnostic or therapeutic procedures.

    Is Fospropofol a strong sedative?

    Fospropofol is a strong sedative. Fospropofol is available only with your doctor’s prescription. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do.

    What is the maximum dose of Fospropofol?

    The recommended maximum dose of fospropofol is 12.5 mg/ kg leading to a loss of consciousness in about 4 min. The recommended effective dose is 6.5 mg/kg.[2]

    What are the side effects of Fospropofol?

    Fospropofol may cause your skin to itch and a side effect called paresthesias. This may cause burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings on your skin. Check with your doctor if you have these symptoms after receiving the injection.