What is a PTEN signaling pathway?
The PTEN network encompasses signals from growth factor receptors on the cell surface to transcription factors that act in the nucleus, complete with interconnections to other tumor suppressor and oncogenic signaling pathways. A simple schematic view of the PTEN pathway is shown in Figure 1.
What regulates PTEN?
PTEN is under extensive regulation by miRNAs. Specific miRNAs target mRNAs by binding to miRNA response elements usually located at the 3′ untranslated region (UTR) of target mRNAs121. A number of miRNAs have been found to participate in the regulation of metabolic disease and cancer by targeting PTEN122,123 (Fig.
How does nuclear PTEN function in health and disease?
Over the last decade, emerging concepts for the complex involvement of nuclear PTEN in a variety of processes, including genome maintenance and DNA repair, cell-cycle control, gene expression, and DNA replication, are illuminating what could prove to be the key path toward a full understanding of PTEN function in health and disease.
What is the function of the PTEN network?
Indeed, the PTEN network regulates a broad spectrum of biological functions, modulating the flow of information from membrane-bound growth factor receptors to nuclear transcription factors, occurring in concert with other tumor suppressors and oncogenic signaling pathways.
What is the role of PTEN in maintaining chromosomal stability?
Our results demonstrate that PTEN plays a fundamental role in the maintenance of chromosomal stability through the physical interaction with centromeres and control of DNA repair. We propose that PTEN acts as a guardian of genome integrity. Animals Cell Nucleus / metabolism*
Is PTEN a PI3K inhibitor or tumor suppressor?
In addition to its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor suppressor in a PI3K-independent manner.