Can linezolid cause serotonin syndrome?
Linezolid is an oxazolidinone antibiotic, which is a weak, reversible, nonselective monoamine oxidase A and B inhibitor; is known to increase serotonin levels, and has been implicated in the development of serotonin syndrome (SS).
Which antibiotic is associated with serotonin syndrome?
SS results from the over-stimulation of serotonin receptors by a variety of mechanisms. New medications with the potential to cause SS are released regularly, and among them is the antibiotic linezolid.
When should I restart SSRI after linezolid?
Treatment with the serotonergic psychiatric medication may be resumed 24 hours after the last dose of linezolid. Serotonergic psychiatric medications should not be started in a patient receiving linezolid. Wait until 24 hours after the last dose of linezolid before starting the antidepressant.
Which drug has a serious interaction with linezolid?
Before using linezolid, report the use of drugs that may increase the risk of extremely high blood pressure (hypertensive crisis) when combined with linezolid, including herbal products (such as ephedra/ma huang), allergy and cold products (including decongestants such as phenylephrine/pseudoephedrine), and stimulants …
What medications interact with linezolid?
Some products that may interact with this drug include: diet pills/appetite suppressants (such as diethylpropion), drugs for attention deficit disorder (such as atomoxetine, methylphenidate), apraclonidine, bupropion, buspirone, carbamazepine, cyclobenzaprine, deutetrabenazine, a certain combination product ( …
Does linezolid cause depression?
It was reported in 2001 to be associated with a case of serotonin syndrome. The association of linezolid with serotonin syndrome has been replicated, and it is now accepted practice to discontinue antidepressant medications when linezolid is to be used. It appears that the risk of depression relapse is not great.